Modafinil is a non-amphetamine central anxious method stimulant with wakefulness-advertising and marketing properties. It really is Employed in the treatment of problems that result in excessive daytime sleepiness.
Medical trials verified that modafinil improves temper in wholesome subjects but may well cause panic.[17]
The FDA would not endorse modafinil for kids's health care problems as a result of a heightened possibility of scarce but serious dermatological toxicity, manifested as Stevens–Johnson syndrome that is a style of significant pores and skin response.
You should not use this medicine When you've got ever had an allergic response or skin rash when getting modafinil or armodafinil (Nuvigil).
Although it can help Many individuals, this medication might sometimes cause dependancy. This possibility may very well be higher Should you have a compound use disorder (which include overuse of or addiction to medication/Alcoholic beverages).
Individuals with SWD concluded electronic diaries that contained questions on sleepiness, sleep, and caffeine use throughout the night time change and over the commute house.
The regulation of modafinil for a doping agent is controversial from the sporting world, with high-profile conditions attracting push protection given that a number of prominent American athletes examined beneficial to the compound. Some athletes who utilised modafinil protested which the drug was not to the prohibited record at some time in their offenses.
In unusual conditions, Provigil might cause a serious rash in the first number of months of having it. It may happen as well as vomiting and fever, and may produce problems with the liver, lungs, kidneys, and coronary heart.
Narcolepsy: Initial-line cure; Modafinil is made use of to treat the daytime fatigue linked to narcolepsy, and it hasn't been proven to boost indicators of cataplexy.
Although It is far from entirely regarded which procedures lead to an animal to get awake or asleep, investigation has demonstrated that a variety of techniques are characteristically Lively all through wakefulness and thus suspected to Engage in a task in servicing of vigilance. The monoaminergic technique, Particularly, has received attentention for its action inside the sleep wake cycle.
Sufferers enrolled in these scientific tests had a diagnosis of OSA, SWD, or narcolepsy and were being necessary to fulfill recognized requirements for extreme sleepiness. Inside the OSA scientific studies, study drug was administered along side ongoing CPAP therapy.
Simply because modafinil’s steps are more qualified and selective, it is thought to deliver a “smoother,” considerably less jittery Strength, have much less critical Uncomfortable side effects, and be much better tolerated that has a reduce potential for abuse or addiction than amphetamines.[6]
Modafinil wasn't noticed to advertise overuse or misuse, even in people who have a background of copyright dependancy.[124] get more info Regardless of the First belief that modafinil carried no abuse probable, emerging evidence suggests that it really works at the exact same neurobiological mechanisms as other addictive stimulants.
de Saint Hilaire et al (2001) calculated arousal with EEG and native brain monoaminergic degrees using microdialysis during the prefrontal cortex plus the ventromedial preoptic area from the hypothalamus in rats presented modafinil.